Warning that Hormone Replacement Therapy Nullifies Benefits of Exercise in Breast Cancer Risk-Reduction

warning

BY ED SUSMAN

 

CHICAGO–Physical activity is known to reduce the risk of breast cancer–but all the benefit of that activity appears to be negated by taking hormone replacement therapy. That is the conclusion of a meta-analysis reported here at the American Society of Clinical Oncology Annual Meeting (Abstract 1561).

 

“If you are a runner you should not take hormone replacement therapy because the hormones appear to wipe out the benefit as far as prevention of breast cancer is concerned,” Cécile Pizot, MS, a biostatistician at the International Prevention Research Institute in France, said in an interview at her poster study.

 

“A lower risk of breast cancer among physically active women has been frequently reported, but the risk in women using hormone replacement therapy appears to be higher.”

 

Asked for her perspective, Stephanie Bernik, MD, Chief of Surgical Oncology at Lenox Hill Hospital in New York City, said: “Although it has been known that physical activity could reduce the risk of breast cancer and that hormone replacement could increase the risk of the disease, it is interesting that this meta-analysis showed that hormone replacement could actually negate the positive effects of exercise.

 

“Women who exercise often want to do what they can to feel young and stay healthy,” she continued. “Although we have known the negative effects of hormone therapy, doctors now have persuasive evidence that the negative effects of hormone replacement therapy override the positive effect of physical activity. Women should be encouraged to do what they can to live healthy lifestyles, with the understanding that it is difficult to justify the use of hormone replacement therapy as part of that equation.”

Memory problems may be linked to “Cancer” Brain, not “Chemo Brain.”

Memory problems and cognitive impairment in women with breast

cancer have traditionally been blamed on “chemo brain,” but a new

study shows that there may be problems even before patients start

on chemotherapy and suggests that cognitive problems may be

linked to cytokines released by the cancer.

The study was published online June 22 in the Journal of the National

Cancer Institute.

The study is the first to describe a relationship between cytokines and

patients with newly diagnosed breast cancer who have not yet

received any cancer treatment.

“Cognitive dysfunction in breast cancer patients has traditionally been

attributed to the effects of chemotherapy (‘chemo brain’). However,

our findings indicate that it is present even prior to any cancer

treatment,” commented first author Sunita Patel, PhD, a clinical

neuropsychologist at City of Hope Medical Center, in Duarte,

California.

In general, “chemo brain” refers to the side effects of chemotherapy,

whereas “cancer brain” includes cognitive problems related to many

factors involved in cancer, including stress, she explained.

“It may be helpful for patients who are fearful about cognitive side

effects of chemotherapy to know that new research suggests non-

treatment-related factors play a role,” Dr Patel added.

Medscape.comChemo_Brain_Cancer_Treatment_Side_Effects

Pink Power Party supporting the VBCAG on Friday, August 28th at Nina McLemore

NINA MCLEMORE
If you are looking to support women in our community with breast cancer AND can use a good shopping spree, please join us on Friday, August 28th at Nina McLemore in Vail!

Nina McLemore and Hostess Joyce Bradley invite you to a
PINK POWER PARTY to benefit The Vail Breast Cancer Awareness Group Friday, August 28.

Pink Cocktails 3 – 5pm
Nina McLemore Boutique 183 Gore Creek Drive. Vail

15% of sales will be donated Aug. 28 – Sept. 3 upon request

RSVP for Cocktail Party 970.476.4809 or vail@ninamclemore.com
www.ninamclemore.com

High Altitude Society column: Annual Celebration of Life luncheon shines on

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VAIL — On July 10, the Vail Marriott Mountain Resort was full of beautiful women dressed to the nines at the Celebration of Life Luncheon in support of the Vail Breast Cancer Awareness Group. These ladies who lunch — and a few great men — make a real difference in the lives of those battling breast cancer in our area. Since 1994, The Vail Breast Cancer Awareness Group has played a critical role in bringing support to those diagnosed with breast cancer in Eagle County. They are dedicated to making their journey as easy as possible. Thanks to their signature event, the Celebration of Life luncheon, they have raised over a million dollars to fulfill their vision to fund those who fight this disease each day.

Board Member Brenda Himelfarb greeted the attendees and gave them an update.

“We give $500 to each person diagnosed with cancer … we have given hundreds of thousands of dollars to Vail Valley Medical Center for various machines and programs. We have the ‘Shine On’ bag (full of pampering gifts), which we give to every person diagnosed. We really want to make everyone’s lives easier who are dealing with breast cancer,” Himelfarb said.

Vice President of the Shaw Regional Cancer Center Peggy Carey was invited to speak and present the check.

“Thank you and welcome everyone and thank you Vail Breast Cancer Awareness Group for bringing Dr. Susan Love to talk with us today. We are lucky to have her here,” Carey said.

Dr. Love has dedicated her professional life to the eradication of breast cancer. As the chief visionary officer of the Dr. Susan Love Research Foundation, she oversees an active research program centered on breast cancer cause and prevention.

AUTOMATED BREAST ULTRASOUND UNIT

“Thank you to all for supporting your community and your friends and neighbors,” Carey continued. “This year the funds raised will go to an automated breast ultrasound unit.”

Colleen Berga, manager at the Sonnenalp Breast Center at the Shaw Cancer Center explained that the ultrasound machine “is specifically for dense breasted women that can benefit from additional breast health surveillance and is meant to complement screening mammography. The new equipment will provide greater patient comfort, quicker scan time and a 3D reconstructed image providing more detail for our breast radiologists.”

VBCAG Board Member of seventeen years, Joyce Bradley, announced that besides herself, co-founder Brenda Himelfarb and longtime member Nikki Denton, the group is working with a whole new board of directors. The group extended their sincere gratitude to the many table organizers, sponsors and individual contributors for their generous support. Please visitwww.vailbreastcancerawareness.org to learn more about the group’s mission and programs.

Betty Ann Woodland covers social events including fundraisers for nonprofits, local happenings and soirees of all kinds. She can be reached at highaltitudesociety@vaildaily.com.

Dietary Intervention May Prime Triple-Negative Breast Cancer for Targeted Therapy

fruits and veggies

By The ASCO Post
Posted: 7/17/2015

Methionine is abundant in meat, fish, some legumes, and nuts but low in fruits

and vegetables.

A low-methionine diet that starves triple-negative breast cancer cells of an

essential nutrient primes the cancer cells to be more easily killed by a targeted

antibody treatment, according to a study published in Clinical Cancer Research.

The study’s senior author, Vincent Cryns, MD, Professor of Medicine at the

University of Wisconsin School of Medicine and Public Health, said the study lays

the foundation for a clinical trial to see whether a low-methionine diet will help

improve outcomes in women with triple-negative breast cancer.

Patients with triple-negative breast cancer have limited treatment options

because their tumor cells lack the three receptors—estrogen, progesterone, and

human epidermal growth factor receptor 2 (HER2)—commonly targeted in

hormone or chemotherapy.

Scientists have known for decades that methionine deficiency can block the

growth of many types of cancer, but the underlying mechanisms have puzzled

researchers.

“We’ve shown that removing methionine can have a specific effect on a

molecular pathway that regulates cell death to increase the vulnerability of

cancer cells to treatments that target this pathway,” Dr. Cryns said. “What’s

particularly exciting about our findings is that they suggest that a dietary

intervention can increase the effectiveness of a targeted cancer therapy.”

Dr. Susan Love to speak at July 10th Luncheon

Love 2

Contact: info@vailbreastcancerawareness.org or call 970.479.8595 to make reservations.  Luncheon will be held at the Marriott in Vail on Friday, July 10th from 11-2pm.

Susan M. Love, MD, MBA has dedicated her professional life to the eradication of breast cancer. As Chief Visionary Officer of Dr. Susan Love Research Foundation, she oversees an active research program centered on breast cancer cause and prevention.
Her activist reputation comes from her role as one of the “founding mothers” of the breast cancer advocacy movement in the early 1990’s as one of the founders of the National Breast Cancer Coalition (NBCC).
Dr. Susan Love is best-known as a trusted guide to women worldwide through her books and the Foundation website. Dr. Susan Love’s Breast Book, deemed “the bible for women with breast cancer” by The New York Times, was released in its fifth edition in October 2010.
A true visionary, Dr. Love’s recent projects include the Army of Women®, an innovative solution to partner women and scientists to accelerate basic translational research. The campaign has recruited more than 376,000 women who have registered to participate in research to find the cause and prevention of breast cancer. In October 2012, Dr. Susan Love Research Foundation launched the Health of Women [HOW] Study™, an online cohort study to identify the cause of breast cancer.
In June of 2012, Dr. Love was diagnosed with leukemia. Following a successful stem cell transplant from her sister, she is back at work and more impatient than ever to find the cause of breast cancer and end it once and for all.

Physicists and biologists are teaming up to model the intricate dance of cells in the body.

human_body_field1-600x213

Flesh really does crawl. Crowds of cells can surge forward together, form

gyrating swirls and waves, segregate into types, and send off meandering

tendrils or mobile exploratory clusters. Collective cell motions are crucial for

everything from embryo development to wound healing to cancer metastasis.

These cell colonies seem to move in concert, almost like flocks of birds, shoals of

fish, or herds of wildebeest.

Some scientists are taking note of these parallels, hoping to find crucial clues

about how cells coordinate. A burgeoning field of research on collective cell

motion is drawing on mathematics originally developed to model animal flocks.

The goal is to find order in the cellular melee and reveal how distant cells can

coordinate their actions to move in unison. “We want to know if we can begin to

find some general behavior in these systems,” says Cristina Marchetti of

Syracuse University, New York. For all that’s known about cells, their coordinated

movement largely remains a mystery, one that cell-motion models may help to

solve.

“It suggests that cancers spread in clumps or crowds not cells, forming gyrating

swirls and waves,” says Dr. Susan Love, Chief Visionary Officer, Dr. Susan Love

Research Foundation. “These cell colonies seem to move in concert, almost like

flocks of birds, shoals of fish or herds of wildebeest.” Science is so cool!”

Dr. Susan Love to Speak at July 10 “Celebration of Life” Luncheon

Susan M LoveDr. Susan Love, regarded as one of the most trusted and respected women’s

health specialists in the United states, and “founding mother “ of the breast

cancer advocacy movement, will be the featured speaker at the Vail Breast

Cancer Awareness Group’s (VBCAG) 21st Anniversary “Celebration of Life”

luncheon. The annual event will be held on Friday, July 10, at the Vail Marriott

Mountain Resort and Spa.

Dr. Love has dedicated her professional life to the eradication of breast cancer.

She is the Chief Visionary Officer of the Dr. Susan Love Research Foundation

and oversees an active research program centered on breast cancer cause and

prevention. She co-founded the National Breast Cancer Coalition and was

appointed by President Bill Clinton to serve on the National Cancer Advisory

Board from 1998-2004. Love served as Clinical Professor of Surgery at the David

Geffen School of Medicine at UCLA and was the first Director of the

Revlon/UCLA Breast Center. Dr. Susan Love’s Breast Book, now in its fifth

edition and available in seven languages, has been deemed “the Bible for

women with breast cancer” by the New York Times. Love is currently working on

the sixth edition of the book, due out in October, and will bring the audience up to

date on “breast cancer in the 21st century.”

“We are thrilled to bring Dr. Love back to the valley,” says Brenda Himelfarb,

president of the VBCAG. “She is down to earth, amazingly entertaining while

speaking on such a serious subject and a true visionary as evident in the Dr.

Susan Love Research Foundation’s Health of Women Study, the largest long-

term online study to identify the cause of breast cancer.”

In June of 2012, Dr. Love was diagnosed with leukemia. Following a successful

stem cell transplant from her sister, she went back to work and more impatient

than ever to find the cause of breast cancer and end it once and for all. She is

also running marathons – in her spare time!

The VBCAG began in 1993. In addition to Himelfarb, board members include

Joyce Bradley, Nicole Denton, Heidi Bricklin, Lori Brown, Eric Burgund, Tracy

Gillette, Jessica Denton, and Linda Lund. The group strives to ease

the financial and emotional burdens endured by those in Eagle County who are

battling breast cancer. Since it’s inception, the VBCAG has raised well over

$1,000,000.

For sponsor opportunities and more information, please call 970-479-8595 or

email info@vailbreastcancerawareness.org

“Pink” Painting Available for Purchase

Pink
This painting is dedicated to Breast Cancer Awareness.  Her name is Pink (the essence of femininity).  She is radiantly aware of her joyful grace, health, and beauty.  Her gift is her everlasting presence with your donation of $3,600 to The Vail Breast Cancer Awareness Group.  

Keep her in Bloom!

Thank You,

Britten

Dimenstions: 30×30

Cost: $3600

Contact: Vail Breast Cancer Awareness Group

info@vailbreastcancerawareness.org or 970.479.8595

Thank you for making our 20th annual Celebration of Life Luncheon a success!

COLL 14
THANK YOU to our wonderful community and everyone that has supported us over the last 20 years. Our 20th annual Celebration of Life Luncheon was a huge success and we couldn’t have done it without you! We appreciate you more than you know <3

A special thanks to our wonderful sponsors, some of whom have been with us since the beginning.

SILVER

Vail Valley Medical Center/Shaw Regional Cancer Center

BRONZE

Mikki Futernick

HOT PINK

Amanda McHugh

Ascent Sotheby’s International Realty

Brenda McHugh

Elaine Kelton

PINK

The Arrabelle Club

Lisa Brill

Deborah Courtney

Diversified Radiology

East West Partners/East West Resorts

FirstBank

Tracy Gillette

The Golden Bear

RA Nelson

Slifer Smith & Frampton

The Vail Daily

US Bank

Vail Marriott Mountain Resort & Spa

Vail Resorts

Patti Weinstein

 

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